Essay at once
DRUGS TO TREAT CANCERS & DRUGS TO TREAT NAUSEA AND VOMITING OBJECTIVES
1. State the cause for the use of antineoplastic agents in the manipulation of cancer. Antineoplastic agents (cell circle of time specific or cell cycle nonspecific) target rapidly growing cells – malignant cells expeditiously divide (uncontrolled growth) and are powerless to repair DNA damage. Also used in the manner that adjuvant for post-excision of tumefaction to prevent recurrence of cancer.
2. Outline the phases of the enclosed space division cycle.
G0 Phase: cells are inert or latent
G1 Phase: cells become greater in size and synthesize RNA and proteins according to DNA synthesis S Phase: formation of RNA, proteins, and enzymes that must be for DNA synthesis G2 Phase: in greater numbers RNA and protein synthesis occurs in combination for mitosis Mitosis: cell division (prophase, metaphase, anaphase, telophase, cytokinesis)
3. Define organic unit cycle-specific, cell cycle-nonspecific, mitosis, generation time, growth fraction, nadir, first direct kinetics, extravasation, vesicant, irritant, palliative, emetogenic, alopecia, and dangerous drug. Cell cycle specific – chemotherapeutic drugs that are chiefly effective during a particular phase of the round of years Cell cycle nonspecific – chemotherapeutic drugs that act independently of a especial cell cycle Mitosis – cell division, that consists of prophase, metaphase, anaphase, telophase (and cytokinesis); 5th phasis of cell cycle Generation time – time needed to consummate the cell cycle; varies w/ reaped ground type of cell; tumors w/ near generation time/rapid mitotic rate are chiefly sensitive to antineoplastic agents/chemotherapy agents Growth Fraction – fraction of tumor’s cell population that is in somewhat active phase of the cell cycle Nadir – period during which the greatest cytotoxic effect of the drug is exerted adhering the bone marrow, causing the lowest blade cell count; the WBC nadir occurs w/i 10-14 days hind the drug is given, and convalescence is w/i 21 days First subordinate class kinetics – principle that the number of tumefaction cells killed by...
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